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Croatica Chemica Acta, Vol. 71 No. 1, 1998.

Preliminary communication

First Hydroxamic Seconucleoside Derivatives

Valerije Vrček ; Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, 10001 Zagreb, Croatia
Vesna Čaplar ; Laboratory of Supramolecular and Nucleoside Chemistry, Rugjer Bošković Institute, P.O.B. 1016, 10001 Zagreb, Croatia
Stanko Uršić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, 10001 Zagreb, Croatia

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Abstract

Nucleoside analogues possessing hydroxamate moiety were prepared from secouridine derivatives oxidized at C(2’)-position. 3’,5’-OIsopropylidene-2’,3’-secouridine was oxidized with CrO3/py complex to the carboxylate level and with DMSO/DCC to the aldehyde level. Both compounds (precursors) gave C(2’)-nucleoside hydroxamic acids in the reaction with hydroxylamine or nitrosobenzene in the presence of Fe3+ ions, respectively.

Keywords

Hrčak ID:

132329

URI

https://hrcak.srce.hr/132329

Publication date:

2.3.1998.

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