Original scientific paper

The Influence of Lower Alcohols on the Surface Lipid Monolayer in LDL

Marina Kveder ; Ruđer Bošković Institute, P.O.B. 1016, 10001 Zagreb, Croatia
Greta Pifat ; Ruđer Bošković Institute, P.O.B. 1016, 10001 Zagreb, Croatia
Slavko Pečar ; J. Stefan Institute, 61000 Ljubljana, Slovenia
Milan Schara ; J. Stefan Institute, 61000 Ljubljana, Slovenia

Abstract

Interaction of methanol, ethanol, propanol and butanol with human plasma low density lipoproteins (LDL) was studied in this work. The surface lipid monolayer of LDL was spin labeled and the electron spin resonance (ESR) spectra were measured in the presence and absence of alcohols. The decomposition of the complex ESR spectra was performed via theoretical simulations of experimental data. The results gained from this study indicate that the influence of alcohol could be observed through the changes of lipid ordering in the surface of LDL monolayer. This observation supports the hypothesis on the mechanism of alcohol action through its interference with lipid-protein interactions at the level of macromolecular surface.

Keywords

Hrčak ID:

132335

URI

https://hrcak.srce.hr/132335

Publication date:

2.3.1998.

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