Original scientific paper

A Methylene Blue-Selective Membrane Electrode Using Methylene Blue-Phosphotungstate as Electroactive Material and its Pharmaceutical Applications

Meng Liang Wen ; Department of Chemistry, Yunnan University, Kunmimg, Yunnan 650091, People’s Republic of China
Yi Bin Zhao ; Department of Chemistry, Yunnan University, Kunmimg, Yunnan 650091, People’s Republic of China
Xiang Chen ; Department of Chemistry, Yunnan University, Kunmimg, Yunnan 650091, People’s Republic of China
Chang Yi Wang ; Department of Chemistry, Yunnan University, Kunmimg, Yunnan 650091, People’s Republic of China

Abstract

A methylene blue poly (vinyl chloride) membrane electrode based on methylene blue-phosphotungstate ion-pair complex as electroactive material is described. The linear response covered the range of 1 × 10–3 – 1 × 10–6 mol dm–3 methylene blue solution, with a slope of 51.5 ±0.8 mV/decade (pH range 3.0–10.0). The detection limit was 6.79 × 10–7 mol dm–3. The electrode showed stability, good reproducibility and a fast response. Interferences from common inorganic cations and some organic bases were negligible. These characteristics of the electrode enabled its successful use for determination of methylene blue in injection. There was good agreement for the results of methylene blue content in injection between the potentiometric method and the United States Pharmacopoeia standard procedure.

Keywords

Hrčak ID:

132395

URI

https://hrcak.srce.hr/132395

Publication date:

1.10.1998.

Visits: 994 *