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Croatian Journal of Infection, Vol. 33 No. 3, 2013.

Professional paper

Analysis and the results of serological testing of Croatian organ donors from 2006 to 2012

Ivanka Mihaljević ; Hrvatski zavod za transfuzijsku medicinu, Referentni centar MZ za transfuzijsku medicinu, Zagreb, Hrvatska
Manuela Miletić Lovrić ; Hrvatski zavod za transfuzijsku medicinu, Referentni centar MZ za transfuzijsku medicinu, Zagreb, Hrvatska
Melita Balija ; Hrvatski zavod za transfuzijsku medicinu, Referentni centar MZ za transfuzijsku medicinu, Zagreb, Hrvatska
Irena Jukić ; Hrvatski zavod za transfuzijsku medicinu, Referentni centar MZ za transfuzijsku medicinu, Zagreb, Hrvatska
Mirela Bušić ; MZ RH, Zavod za transplantaciju i biomedicinu, Zagreb, Hrvatska

Full text: croatian pdf 231 Kb

page 117-125

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Abstract

Introduction: The success of transplantation and graft survival are closely related to the absence of infection in transplant recipients through infected graft, reactivated recipient's latent infections, nosocomial infections and community acquired infections. Since 2006, the Croatian Institute of Transfusion Medicine has been providing mandatory testing of organ donors (OD) for bloodborne pathogens (24/7) for the entire country.
Materials and methods: In the period from 5.11.2006. to 31.12.2012. a total of 642 organ donor plasma samples were tested by means of Abbott – Architect and bioMerieux – Vidas tests. In this paper, the quality of samples measured against rate of dilution, turnaround time and prevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), T. pallidum and T. gondii markers were analyzed.
Results: Seroprevalence of EBV, CMV and Toxoplasma gondii was as high as expected (96.8%, 92% and 71%, respectively). There were no HIV positive OD, while in 0.5% HBsAg, in 8.9% anti-HBc, in 1.6% anti-HCV, in 1.3% HCVAg and in 0.8% T. pallidum Ab were found positive. 2.5% of the samples were diluted by more than 50% and the average testing time per OD was 2.04 hours.
Conclusion: The results indicate the adequacy of organ donor selection methods in donor hospitals, appropriate tests and testing algorithms used. The prevalence of pathogens is in accordance with epidemiological characteristics of the general population.

Keywords

Organ donors; serological tests; transplantation; infection

Hrčak ID:

133433

URI

https://hrcak.srce.hr/133433

Publication date:

30.9.2013.

Article data in other languages: croatian

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