Case report
Creutzfeldt-Jakob disease in clinical practice: a case report
Zdravko Andrić
; Opća županijska bolnica Požega, Požega, Hrvatska
Tomislav Baica
; Opća županijska bolnica Požega, Požega, Hrvatska
Dobrinka Petković
; Opća županijska bolnica Požega, Požega, Hrvatska
Irena Gašparić
; Opća županijska bolnica Požega, Požega, Hrvatska
Borislav Vuković
; Opća županijska bolnica Požega, Požega, Hrvatska
Abstract
We describe a 56-year-old female patient presenting with a very short course of disease since the onset of symptoms until death that was diagnosed with Creutzfeldt-Jakob disease (CJD). The disease began with confusion, disorientation, forgetfulness and insomnia that lasted only several days prior to the admission to the Department of Psychiatry of the General Hospital Požega. Progression of mental disorders and mental decline rapidly continued during hospitalization with progressive development of neurological symptoms: more frequent tics, periodic myoclonus, unusual facial grimaces and incoherent screams with development of urinary retention. The patient soon became unconscious. Routine initial laboratory findings of blood and CSF tests, with brain MSCT and MRI and EEG findings, were either normal or nonspecific, as well as serological tests to neurotropic pathogens, B. burgdorferi and Bartonella. During the third week of hospitalization, the control EEG finding showed a triphasic spikewave complex, characteristic of CJD. Subsequently performed CSF tests for detection of characteristic proteins confirmed the diagnosis: NSE was 16.1 μg/L, Tau-protein >1200 ρg/mL, S-100B protein >4.25 μg/L, with a positive 14-3-3 protein. In the absence of specific treatment, and after implementing all the measures of symptomatic treatment and care, the patient died four and a half months after the onset of the disease.
Keywords
Creutzfeldt-Jakob disease; electroencephalography; prions
Hrčak ID:
133435
URI
Publication date:
30.9.2013.
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