Review article
Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment
Christoph Seger
Andrea Griesmacher
Full text: croatian pdf 691 Kb
page 29-51
downloads: 846
cite
APA 6th Edition
Seger, C. & Griesmacher, A. (2007). Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment. Biochemia Medica, 17 (1), 29-51. Retrieved from https://hrcak.srce.hr/12858
MLA 8th Edition
Seger, Christoph and Andrea Griesmacher. "Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment." Biochemia Medica, vol. 17, no. 1, 2007, pp. 29-51. https://hrcak.srce.hr/12858. Accessed 6 May 2024.
Chicago 17th Edition
Seger, Christoph and Andrea Griesmacher. "Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment." Biochemia Medica 17, no. 1 (2007): 29-51. https://hrcak.srce.hr/12858
Harvard
Seger, C., and Griesmacher, A. (2007). 'Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment', Biochemia Medica, 17(1), pp. 29-51. Available at: https://hrcak.srce.hr/12858 (Accessed 06 May 2024)
Vancouver
Seger C, Griesmacher A. Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment. Biochemia Medica [Internet]. 2007 [cited 2024 May 06];17(1):29-51. Available from: https://hrcak.srce.hr/12858
IEEE
C. Seger and A. Griesmacher, "Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment", Biochemia Medica, vol.17, no. 1, pp. 29-51, 2007. [Online]. Available: https://hrcak.srce.hr/12858. [Accessed: 06 May 2024]
Full text: english pdf 691 Kb
page 29-51
downloads: 473
cite
APA 6th Edition
Seger, C. & Griesmacher, A. (2007). Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment. Biochemia Medica, 17 (1), 29-51. Retrieved from https://hrcak.srce.hr/12858
MLA 8th Edition
Seger, Christoph and Andrea Griesmacher. "Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment." Biochemia Medica, vol. 17, no. 1, 2007, pp. 29-51. https://hrcak.srce.hr/12858. Accessed 6 May 2024.
Chicago 17th Edition
Seger, Christoph and Andrea Griesmacher. "Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment." Biochemia Medica 17, no. 1 (2007): 29-51. https://hrcak.srce.hr/12858
Harvard
Seger, C., and Griesmacher, A. (2007). 'Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment', Biochemia Medica, 17(1), pp. 29-51. Available at: https://hrcak.srce.hr/12858 (Accessed 06 May 2024)
Vancouver
Seger C, Griesmacher A. Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment. Biochemia Medica [Internet]. 2007 [cited 2024 May 06];17(1):29-51. Available from: https://hrcak.srce.hr/12858
IEEE
C. Seger and A. Griesmacher, "Some important aspects of implementing tandem mass spectrometry in a routine clinical laboratory environment", Biochemia Medica, vol.17, no. 1, pp. 29-51, 2007. [Online]. Available: https://hrcak.srce.hr/12858. [Accessed: 06 May 2024]
Abstract
During past years, the combination of high performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS), also known as HPLC-MS/MS, matured to reliable analytical instrumentation. Its application in therapeutic drug monitoring (TDM) has been shown to be superior to normally applied immunoassays. Especially in the context of immunosuppressant medication level surveillance, this technique has become an indispensable tool in many clinical laboratories and is considered the gold standard. However, setting up a HPLC-MS/MS platform is demanding in terms of assay validation and the robustness of testing. This review is to provide a rough guideline aiding the implementation process of such a platform into a routine clinical environment.
Keywords
tandem mass spectrometry; targeted analysis; therapeutic drug monitoring; routine analysis; high performance liquid chromatography; HPLC-MS/MS
Hrčak ID:
12858
URI
https://hrcak.srce.hr/12858
Publication date:
7.6.2007.
Article data in other languages:
croatian
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