Biochemia Medica, Vol. 17 No. 1, 2007.
Short communication, Note
Why is it necessary to recognize macroenzymes?
Ivana Čepelak
Dubravka Čvorišćec
Abstract
Macroenzymes are complexes consisting of normal enzymes or isoenzymes generated by their polymerization, mostly by their linking to immunoglobu-lins, some lipoproteins, proteins, or cell membrane fragments. Generally, macroenzymes are characterized by a greater molecular mass and longer half-life in systemic circulation. The occurrence of macroenzymes in serum may influence analytical measurement of an enzyme activity or may cause erroneous interpretation of elevated enzyme activity due to inadequate understanding of the clinical relevance of the presence of macroenzymes.
Keywords
macroenzymes; macro creatine kinase; immunoglobulins
Hrčak ID:
12862
URI
Publication date:
7.6.2007.
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