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Signa vitae : journal for intesive care and emergency medicine, Vol. 9 No. Suppl. 1, 2014.

Original scientific paper

Procalcitonin vs C-reactive protein in early detection of intrauterine infection in premature rupture of membranes and neonatal infections

Vesna Elveđi Gašparović orcid id orcid.org/0000-0002-0960-3989 ; Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, Zagreb, Petrova 13, 10 000 Zagreb
IVANA MAURAC ; Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, Zagreb, Petrova 13, 10 000 Zagreb
PETRANA BELJAN ; Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, Zagreb, Petrova 13, 10 000 Zagreb
SNJEŽANA GVERIĆ-AHMETAŠEVIĆ ; Department of Obstetrics and Gynaecology, Neonatal Intensive Care Unit, University Hospital Centre Zagreb, Zagreb, Croatia
SONJA ANIĆ JURICA ; Department of Obstetrics and Gynaecology, Neonatal Intensive Care Unit, University Hospital Centre Zagreb, Zagreb, Croatia

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Abstract

At any time during pregnancy intrauterine infection is an important risk factor for neonatal sepsis and is a frequent cause
of mortality and morbidity in newborn infants. The aim of this study was to consider the patterns of procalcitonin (PCT) response
in normal pregnancy and in pregnancies complicated with a premature rupture of the membranes, to compare the
results of PCT with those of C-reactive protein (CRP) and to assess their diagnostic accuracy both to mothers and neonates.
120 mothers with singleton pregnancies were enrolled in this study. 60 pregnancies were complicated with a premature
rupture of membranes, and 60 were control pregnancies. We analyzed PCT and CRP values, clinical chorioamnionitis, neonatal
infection and other neonatal outcomes in both groups. We found significantly higher maternal serum concentrations
of PCT and CRP in the Study group. Regarding our results, both markers are predictive for chorioamnionitis and neonatal
infections, with almost similar significance.

Keywords

clinical chorioamnionitis; neonatal infection; procalcitonin; C-reactive protein

Hrčak ID:

134160

URI

https://hrcak.srce.hr/134160

Publication date:

1.6.2014.

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