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Signa vitae : journal for intesive care and emergency medicine, Vol. 9 No. Suppl. 1, 2014.

Professional paper

Liver injury after the intravenous amiodarone administration in patient with impaired heart function

ROBERT BARONICA ; Department of Anaesthesiology, Reanimatology and Intensive Care, University Hospital Centre Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia
BOJANA UROVIĆ MRŽLJAK ; Department of Anaesthesiology, Reanimatology and Intensive Care, University Hospital Centre Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia
MARIO PAVLEK ; Department of Anaesthesiology, Reanimatology and Intensive Care, University Hospital Centre Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia
TAJANA ZAH BOGOVIĆ ; Department of Anaesthesiology, Reanimatology and Intensive Care, University Hospital Centre Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia
INA FILIPOVIĆ-GRČIĆ ; Department of Anaesthesiology, Reanimatology and Intensive Care, University Hospital Centre Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia
BORIS TOMAŠEVIĆ ; Department of Anaesthesiology, Reanimatology and Intensive Care, University Hospital Centre Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia
MIRJANA MIRIĆ ; Department of Anaesthesiology, Reanimatology and Intensive Care, University Hospital Centre Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia

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Abstract

While many adverse effects have been associated with long-term oral amiodarone therapy, acute hepatotoxicity from intravenous
administration of amiodarone is a rare side effect. This case report focuses on a 78-year-old critically ill female, who
underwent several urgent surgical procedures and had elevated liver aminotransferases concentrations after the intravenous
administration of amiodarone for the treatment of atrial fibrillation. Also, the patient developed heart failure with reduced
left ventricular systolic function. Immediately after the discontinuation of amiodarone therapy, liver aminotransferases levels
began to decline. Our case suggests that regular monitoring of hepatic function is required in patients receiving intravenous
amiodarone, especially in the setting of impaired heart function and possible liver hypoperfusion.

Keywords

amiodarone; hepatotoxicity; heart failure

Hrčak ID:

134169

URI

https://hrcak.srce.hr/134169

Publication date:

1.6.2014.

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