Review article

New antimicrobial drugs

N. Bradarić
I. Bradarić
I. Curić
N. Kuzmičić

Abstract

In this article we present a brief summary of new antibiotics that were registered in Republic of Croatia in period from 2000.–2005. We stated the basic pharmacokinetic characteristics of moxifloxacine, linezolide, levofloxacine, cefipime, and telitromycine. We mentioned newer antibiotics that are registered or are waiting registration in other countries around the world like: tigecycline, quinupristine/dalfopristine, daptomycine, ertapeneme, doripeneme, dalbavancine, gemifloxacine, gatifloxacine, sitafloxacine, sparfloxacine, fosfamycine, ceftizoksim alapivoksil. Finally we listed antibiotics that are currently in various stages preclinical and clinical development around the world, most of that are still coded with numbers and/or letters. For antibiotics from the last two groups we mentioned their antibiotic classes, and for all three groups we listed their clinical indications. We discussed problems that lead to a hold in antibiotic development, and the growing need for development of newer potent antibiotics as a solution for the problem of resistant bacteria more of which emerge every day. We mentioned the basic future trends that will lead to development of newer antimicrobial drugs.

Keywords

Antibiotics; antimicrobial treatment; resistance

Hrčak ID:

12687

URI

https://hrcak.srce.hr/12687

Publication date:

14.9.2006.

Article data in other languages: croatian

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