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Acta Pharmaceutica, Vol. 65 No. 3, 2015.

Short communication, Note

https://doi.org/10.1515/acph-2015-0023

Investigation of the effects of vitamin D and calcium on intestinal motility: In vitro tests and implications for clinical treatment

GUGLIELMO GIRALDI ; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy
ANGELO FIORAVANTI ; Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Italy
EUGENIA DE LUCA D’ ALESSANDRO ; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy
MAURA PALMERY ; Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Italy
LUCIA MARTINOLI ; Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Italy

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Abstract

The presence of vitamin D receptors in small intestine muscle cells may lead one to think that vitamin D may act locally, influencing intracellular calcium concentration and contributing to the contraction-relaxation regulation of the intestinal smooth muscle cells. This study investigates the potential effects of vitamin D and calcium on intestinal motility using an in vitro test.
Different calcium concentrations added to the tissue not pre-treated with 1,25-dihydroxycholecalciferol [1α,25(OH)2D3] produced no response at low doses (1.25×10–3 and 2.0×10–3 mol L–1) and only a very weak response at higher concentration (3.0×10–3 mol L–1). The addition of 1α,25(OH)2D3 (1.44×10–10 mol L–1) had no effect on isolated ileum motility. When calcium (3.0×10–3 mol L–1) was added after at least 3 hours, it evoked evident and persistent contractions for 60-90 minutes. The contractions were at about 40 % of the peak produced by acetylcholine.Thus, simultaneous intake of vitamin D and calcium might be a useful co-adjuvant in intestinal atony therapy aimed to stimulate normal gut motility in humans. These findings imply that supplemental vitamin D may be important in all cases where calcium has to be prescribed.

Keywords

vitamin D; calcium; intestinal motility; in vitro tests

Hrčak ID:

134866

URI

https://hrcak.srce.hr/134866

Publication date:

30.9.2015.

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