Acta Pharmaceutica, Vol. 65 No. 3, 2015.
Original scientific paper
https://doi.org/10.1515/acph-2015-0029
Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization
AHMED N. ALLAM
; Faculty of Pharmacy, University of Alexandria, Egypt
IBRAHIM A. KOMEIL
; Medizen Pharmaceutical Industries, Alexandria, Egypt
OSSAMA Y. ABDALLAH
; Faculty of Pharmacy, University of Alexandria, Egypt
Abstract
Curcumin, a naturally occurring lipophilic molecule can exert multiple and diverse bioactivities. However, its limited aqueous solubility and extensive presystemic metabolism restricts its bioavailability. Curcuminphytosomeswere prepared by simple solvent evaporation method where free flowing powder was obtained in addition to a newly developed semisolid formulation to increase curcumin content in softgels. Phytosomal powder was characterized in terms of drug content and zeta-potential. Thirteen different softgel formulations were developed using oils such as Miglyol 812, castor oil and oleic acid, a hydrophilic vehicle as PEG 400 and bioactive surfactants such as Cremophor EL and KLS P 124. Selected formulations were characterized in terms of curcumin in vitro dissolution. TEM analysis revealed good stability and a spherical, self closed structure of curcumin phytosomes in complex formulations. Stability studies of chosen formulations prepared using the hydrophilic vehicle revealed a stable curcumin dissolution pattern. In contrast, a dramatic decrease in curcumin dissolution was observed in case of phytosomes formulated in oily vehicles.
Keywords
curcumin; phospholipid; phytosomes; bioavailability; lipids; softgels
Hrčak ID:
134872
URI
Publication date:
30.9.2015.
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