Original scientific paper
Soluble FAS and transforming growth factor beta 2 in infections with viral and bacterial zoonoses
M. Janković
Lj. Cebalo
O. Đaković-Rode
Z. Milas
N. Turk
A. Markotić
Abstract
We determined levels of sFas (signal receptor molecule released during apoptosis in a soluble circulating form) and TGF-β2 (multifunctional cytokine) in patients with different zoonoses. Serum samples were obtained from patients hospitalized at the University Hospital for Infectious Diseases, Zagreb, Croatia with diagnoses of hemorrhagic fever with renal syndrome – HFRS, (n=20), leptospirosis (n=9), Lyme borreliosis (n=7), or tick-borne encephalitis – TBE (n=7). In all sera samples the levels of sFAS or TGF-β2 levels were measured using ELISAkits according to the manufacturer's protocol. Significant increase in the levels of sFas was found in all patients. However, the patients with TBE or Lyme borreliosis had significantly lower levels than patients with leptospirosis. In contrary, patients with TBE or Lyme borreliosis had significantly higher levels of TGF-β2 than healthy controls. Our preliminary data indicate that an increase of sFas and TGF-β2 levels may have a role in the immunopathogenesis of tested viral and bacterial zoonoses.
Keywords
Hrčak ID:
12652
URI
Publication date:
1.12.2006.
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