Croatica Chemica Acta, Vol. 69 No. 2, 1996.
Original scientific paper
Chemistry of 1,3-Dioxepins. X. Regio and Stereocontrolled Syntheses of Antihyperglycemic N-Sulfonyl-1a,2,6,6a-tetrahydro-1H,4H[1,3] -dioxepino[5,6-b]azirines via Isomeric cis- and trans- Sulfonamidodioxepanols
Darko Filić
; PLIVA Research Institute, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia
Mladen Vinković
; PLIVA Research Institute, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia
Blanka Jamnicky
; PLIVA Research Institute, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia
Miljenko Dumić
; PLIVA Research Institute, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia
Abstract
Regio- and stereocontrolled syntheses of 1-sulfonyl-1a,2,6,6a-tetrahydro-1H,4H[1,3] -dioxepino[5,6-b]azirine 1, the lead compound of a novel class of potent antihyperglycemics, via isomeric cis- and trans-sulfonamidodioxepanols 6 and 13 are described. The constitution and configuration of the key intermediates 6 and 13 were elucidated by independent syntheses and confirmed by the X-ray structure analysis.
Keywords
Hrčak ID:
136675
URI
Publication date:
3.6.1996.
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