Original scientific paper

Complexes of Azithromycin with Some Divalent Metal Ions

Slobodan Đokić ; Pliva Research Institute, Prilaz baruna Filipovića 89, 41001 Zagreb, Croatia
Zlatko Vajtner ; Pliva Research Institute, Prilaz baruna Filipovića 89, 41001 Zagreb, Croatia
Nevenka Lopotar ; Pliva Research Institute, Prilaz baruna Filipovića 89, 41001 Zagreb, Croatia
Draginja Mrvoš-Sermek ; Laboratory of General and Inorganic Chemistry, Faculty of Science, University of Zagreb, Ul. kralja Zvonimira 8, 41000 Zagreb, Croatia
Boris Kamenar ; Laboratory of General and Inorganic Chemistry, Faculty of Science, University of Zagreb, Ul. kralja Zvonimira 8, 41000 Zagreb, Croatia
Ante Nagl ; Institute of Textile and Clothing, Faculty of Technology, University of Zagreb, Croatia

Abstract

The formation of 2 : 1 complexes of azithromycin with copperdl), zincdl), cobaltdl), nickel(II), magnesiumdl) and calciumdl) ions was examined. These compounds (2-7) showed the same in vitro biological potency as azithromycin (1). The complexes (3-7) are isostructural and different when compared with azithromycin-Cu(II)- complex. Copper(II)-complex (2) was most stable and selected for structure determination by X-ray crystallography. Some physical characteristics and analyses of the complexes are also presented.

Keywords

Hrčak ID:

136758

URI

https://hrcak.srce.hr/136758

Publication date:

1.5.1995.

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