Original scientific paper

Dihydropyridine Isomerism in the Chemical Delivery System Series

Emil Pop ; Pharmos Corporation, 2 Innovation Drive, Alachua, FL. 32615
Marcus E. Brewster ; Pharmos Corporation, 2 Innovation Drive, Alachua, FL. 32615
Ming-Ju Huang ; Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, FL. 32610
Nicholas Bodor ; Pharmos Corporation, 2 Innovation Drive, Alachua, FL. 32615

Abstract

A theoretical study was performed for three structured isomers of the dihydropyridine-targetor btised chemical delivery systems of estradiol euid azidothymine. The relative thermodynamic stabilities reflected by the calculated heats of formation (AHf) indicated, in good agreement with avedlable experimental evidence, preferential formation of the 1,4-dihydropyridine isomers as a result of thermodynamic product control. The increased relative stability of the 1,4-isomers, as compared to the 1,2-and 1,6-dihydropyridine, is explained by favorable electronic interactions (hyperconjugation, homoarom- aticily) existent in these derivatives.

Keywords

Hrčak ID:

137054

URI

https://hrcak.srce.hr/137054

Publication date:

1.3.1994.

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