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Original scientific paper

Synthesis of 8-Methyl-1,2,3,4-tetrahydropyrido-[3,4-d]pyrimidine-2,4-diones

Nedjeljko Kujundžić ; Research Institute PLIVA, Zagreb, Croatia
Berislav Glunčić ; Research Institute PLIVA, Zagreb, Croatia

Full text: english pdf 10.791 Kb

page 599-606

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A new method is described for the preparation of 8-methyl-1,2,3,4-tet- rahydropyrido[3,4-d]pyrimidine-2,4-diones 4, and 4-imino-8-methyl-l,2,3,4- -tetrahydropyrido[3,4-d]pyrimidine-2-ones, 3, starting from 4-methyl-5-oxa- zolylureas 1 and substituted olefins.
A plausible mechanism is proposed with a Diels-Alder adduct from the reagents as an intermediate that aromatizes by losing water to yield compounds 3. The latter give the title compounds 4 after hydrolysis.


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