Review article

Genetic predisposition for various forms of spondyloarthritis

Lovro Lamot orcid.org/0000-0002-7939-115X ; Rheumatology Infirmary, Children's Hospital Srebrnjak, Zagreb, Croatia
Mandica Vidović ; Rheumatology Infirmary, Children's Hospital Srebrnjak, Zagreb, Croatia
Marija Perica ; Rheumatology Infirmary, Children's Hospital Srebrnjak, Zagreb, Croatia
Lana Tambić Bukovac ; Rheumatology Infirmary, Children's Hospital Srebrnjak, Zagreb, Croatia
Miroslav Harjaček ; Rheumatology Infirmary, Children's Hospital Srebrnjak, Zagreb, Croatia

Abstract

In addition to the long-established association of HLA-B27 antigen and spondyloarthritis, several studies have shown a similar association with HLA-B7 antigen. But since the whole MHC region carries less than half of the risk for the development of the disease, the main goal of many recently performed researches, which implemented various high-throughput methods, was to discover the influence of genes outside the MHC region on disease development. The results showed that genes closely linked to spondyloarthritis participate in antigen processing and coding of various cytokines. This can lead to the conclusion that diseases from the spondyloarthritis group are polygenic, affected by both autoinflammatory and autoimmune mechanisms.

Keywords

spondyloarthritis; autoimmune diseases; autoinflammatory diseases; gene expression; genetic predisposition

Hrčak ID:

137774

URI

https://hrcak.srce.hr/137774

Publication date:

30.9.2014.

Article data in other languages: croatian

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