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Reumatizam, Vol. 61 No. 2, 2014.

Review article

Pathophysiology of osteoporosis

Jasminka Milas-Ahić ; Clinical Department for Rheumatology, Allergology and Clinical Immunology, Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia
Višnja Prus ; Clinical Department for Rheumatology, Allergology and Clinical Immunology, Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia
Željka Kardum ; Clinical Department for Rheumatology, Allergology and Clinical Immunology, Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia
Ivana Kovačević ; Clinical Department for Rheumatology, Allergology and Clinical Immunology, Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia

Full text: croatian pdf 456 Kb

page 65-69

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Abstract

The balance of degradation and bone formation is important for the normal process of remodeling and maintenance of bone mass. Genetic, hormonal, immunological and other factors affect bone remodeling throughout life. Disorder of bone turnover plays key role in the pathophysiology of osteoporosis and presents a complex process which involves bone cells, cytokines and their receptors. Nowadays, important role of RANK/RANKL/OPG system in the pathophysiology of osteoporosis is well known, but it is still important to investigate the intracellular signaling pathways in the development of osteoporosis and other metabolic bone diseases.

Keywords

pathophysiology; osteoporosis; RANKL; osteoprotegerin; cathepsin K; sclerostin

Hrčak ID:

137900

URI

https://hrcak.srce.hr/137900

Publication date:

23.10.2014.

Article data in other languages: croatian

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