Review article

Targeted therapy in patients with radioiodine-refractory differentiated thyroid cancer (DTC)

DAVORIN HERCEG ; Department of Oncology, University Hospital Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
GORDANA HORVATIĆ HERCEG ; Clinical Department of Nuclear Medicine and Radiation Protection, University Hospital Zagreb, Zagreb, Croatia

Abstract

Papillary (PTC) and follicular (FTC) thyroid cancer (TC) belong to
differentiated thyroid cancer (DTC). The initial treatment of DTC is surgery
followed by radioiodine remnant ablation. Although the prognosis of
DTC is generally good, approximately 10-15% of DTC patients will devolp
advanced disease and their disease will become radioiodine refractory. Even
in radioiodine refractory patients the natural history of disease can be slowly progressive or indolent.The expanded knowledge of the the biological basis of DTC has opened new opportunities in therapy – targeted therapy, aimed at inhibiting specific molecular targets and pathways in tumor proliferation, survival and progression. We rewieved different tageted therapies in DTC. Sorafenib was the first and only targeted drug approved by FDA for progressive and radiodine-refractory DTC. Also, lenvatinib had promising efficacy results in phase III trial, probably even better than sorafenib, but with more treatment-related deaths. The timing of targeted therapy for DTC is of decisive importance. The potential benefit should be balanced with potential toxicity of targeted
therapies.

Keywords

Hrčak ID:

138014

URI

https://hrcak.srce.hr/138014

Publication date:

30.12.2014.

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