Original scientific paper

https://doi.org/10.5562/cca2479

Thermo-Kinetic Investigation of Comparative Ligand Effect on Cysteine Iron Redox Reaction

Masood Ahmad Rizvi orcid.org/0000-0003-0470-6329 ; University of Kashmir, Department of Chemistry, Hazratbal Srinagar, 190006, J&K, India
Norio Teshima ; Aichi Institute of Technology, Department of Applied Chemistry, 1247 Yachigusa, Yakusa-cho, Toyota 470-0392, Japan
Syed Raashid Maqsood ; University of Kashmir, Department of Chemistry, Hazratbal Srinagar, 190006, J&K, India
Showket Ahmad Akhoon ; University of Kashmir, Department of Chemistry, Hazratbal Srinagar, 190006, J&K, India
Ghulam Mustafa Peerzada ; University of Kashmir, Department of Chemistry, Hazratbal Srinagar, 190006, J&K, India

Abstract

Transition metal ions in their free state bring unwanted biological oxidations generating oxidative
stress. The ligand modulated redox potential can be indispensable in prevention of such oxidative
stress by blocking the redundant bio-redox reactions. In this study we investigated the comparative ligand
effect on the thermo-kinetic aspects of biologically important cysteine iron (III) redox reaction using spectrophotometric
and potentiometric methods. The results were corroborated with the complexation effect
on redox potential of iron(III)-iron(II) redox couple. The selected ligands were found to increase the rate
of cysteine iron (III) redox reaction in proportion to their stability of iron (II) complex (EDTA < terpy <
bipy < phen). A kinetic profile and the catalytic role of copper (II) ions by means of redox shuttle mechanism
for the cysteine iron (III) redox reaction in presence of 1,10-phenanthroline (phen) ligand is also reported.

Keywords

ligand effect; bio-redox; cysteine; redox shuttle; reactive oxygen species (ROS)

Hrčak ID:

139131

URI

https://hrcak.srce.hr/139131

Publication date:

27.3.2015.

Visits: 2.675 *