Original scientific paper

https://doi.org/10.5562/cca2420

Electrocatalytic Oxidation of Venlafaxine at a Multiwall Carbon Nanotubes-Ionic Liquid Gel Modified Glassy Carbon Electrode and Its Electrochemical Determination

Ling Ding ; College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, 750021, People’s Republic of China
Lei Li ; Liaoning Research Institute of Light Industry, Shenyang 110004, People’s Republic of China
Wei You ; College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, 750021, People’s Republic of China
Zuo-Ning Gao ; College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, 750021, People’s Republic of China
Tian-Lin Yang ; College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, 750021, People’s Republic of China

Abstract

The electrocatalytic oxidation of venlafaxine (VEN) was investigated at a glassy carbon
electrode (GCE), the modified electrode by a gel containing multiwall carbon nanotubes (MWCNTs) and
a room-temperature ionic liquid (RTIL), 1-butyl-3-methylimidazolium hexafluorophate (BMIMPF6) in
0.10 mol L−1 phosphate buffer solution (PBS, pH 6.8). It was found that an irreversible anodic oxidation
peak of VEN with the peak potential (Epa) as 0.780 V appeared at MWCNTs-RTIL/GCE. The electrode
reaction process was a diffusion-controlled one and the electrochemical oxidation involved two electrons
transferring and two protons participation. Furthermore, the charge-transfer coefficient (α), and the electrode
reaction rate constant (kf) of VEN were found to be 0.91 and 3.04×10−2 s−1, respectively. Under the
optimized conditions, the electrocatalytic oxidation peak currents were linearly dependent on the concentration
of VEN in the concentration range from 2.0×10−6 mol L−1 ~ 2.0×10−3 mol L−1 with the limit of
detection (S / N = 3) as 1.69×10−6 mol L−1. The proposed method has been successfully applied in the electrochemical
quantitative determination of VEN content in commercial venlafaxine hydrochloride capsules
and the determination results could meet the requirement of the quantitative determination.

Keywords

venlafaxine; electrocatalytic oxidation; MWCNTs-RTIL/GCE; GCE electrochemical determination

Hrčak ID:

139133

URI

https://hrcak.srce.hr/139133

Publication date:

27.3.2015.

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