Medicina Fluminensis, Vol. 51 No. 2, 2015.
Professional paper
The estimation of comorbidities and serum concentration of cardiac biomarkers in patients with chronic obstructive pulmonary disease treated with invasive or nonivasive ventilation
Sven Pal
; Dom zdravlja Primorsko-goranske županije, Rijeka
Danijel Knežević
; Katedra za anesteziologiju, reanimatologiju i intenzivno liječenje, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Janja Kuharić
; Katedra za anesteziologiju, reanimatologiju i intenzivno liječenje, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Alan Šustić
; Katedra za anesteziologiju, reanimatologiju i intenzivno liječenje, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Vlatka Sotošek Tokmadžić
; Katedra za anesteziologiju, reanimatologiju i intenzivno liječenje, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Antonija Harjač
; Opća bolnica Varaždin, Varaždin
Robert Marčun
; Sveučilišna bolnica za plućne bolesti i alergije Golnik, Golnik, Slovenija
Mitja Lainščak
; Sveučilišna bolnica za plućne bolesti i alergije Golnik, Golnik, Slovenija
Abstract
Aim: To determine the most common comorbidities in patients with chronic obstructive pulmonary disease (COPD) treated with invasive or nonivasive ventilation, investigate serum concentration of cardiac biomarkers (N-terminal pro-brain natriuretic peptide or NT-proBNP and troponin) in these patients and analyze if type of ventilation affects serum concentrations of cardiac biomarkers. Patients and methods: We analyzed 41 medical records of patients with acute exacerbation of COPD treated with nonivasive or invasive ventilation in University hospital for pulmonary disease and alergies Golnik. Results: The most common comorbidities were arterial hypertension, chronic heart failure and ischemic heart disease. In COPD patients with acute exacerbation treated with nonivasive ventilation NT-proBNP levels were elevated in 23 (100 %) patient and troponin levels were elevated in 3 (14 %) patients. In COPD patients with acute exacerbation treated with invasive ventilation NT-proBNP levels were elevated in 17 (94 %) patients and troponin levels were elevated in 7 (39 %) patients. When comparing NT-proBNP and troponin levels between COPD patients with acute exacerbation treated with noninvasive ventilation and those treated with invasive ventilation the statistically significant difference was not found. Discussion and conclusion: Taking into consideration the common risk factors for development od COPD and cardiovascular diseases, in combination with anatomical and functional relation that exists between cardiovascular and pulmonary system, it is not unusual that this two conditions occur with high prevalence in the same patients. Because of the similar clinical manifestations it is important to actively search for these conditions in order to achieve optimal treatment for the patients.
Keywords
chronic obstructive pulmonary disease; heart failure; myocardial ischemia; NT-proBNP; troponin
Hrčak ID:
139475
URI
Publication date:
1.6.2015.
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