Review article

The skeleton in diabetes – involvement and interaction

Vesna Kušec ; Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia

Abstract

Diabetes mellitus (DM) is characterized by high blood glucose; impairment of the skeleton is among its other deleterious effects. Adverse effect upon the bone tissue is primarily altered bone quality and consequently increased bone fragility. In DM 1, bone mass may be low and in DM2 normal or even increased. Therapy for DM2 also affects bone metabolism as thiazolidine-diones cause differentiation shift of mesenchyme precursors from osteoblasts into adipocytes. Association of bone with glucose metabolism was discovered in the last decade indicating that insulin is necessary for synthesis of undercarboxylated osteocalcin which acts in a hormonal fashion to promote insulin secretion in the pancreas, adiponectin in adipocytes, and increases
insulin sensitivity in target tissues. Undercarboxylated osteocalcin is
also secreted from resorbed bone. Thus insulin is required for normal bone metabolism and bone acts as an endocrine organ. Additional role of osteocalcin is in promoting testosterone secretion in testes.

Keywords

Hrčak ID:

139527

URI

https://hrcak.srce.hr/139527

Publication date:

31.3.2015.

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