Review article
CPR flow to prime the ischemic heart during cardiac arrest?
Mark G Angelos
orcid.org/0000-0001-5771-3245
; Department of Emergency Medicine The Ohio State University Wexner Medical Center 760 Prior Hall, 376 West 10th Ave Columbus, Ohio 43210
Mahmood Khan
; Department of Emergency Medicine, Davis Heart Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210
Abstract
Cardiac arrest is unique among cardiac ischemic syndromes in that all circulation must be generated external to the heart. Although, chest compressions deliver limited blood flow, it may be possible to take advantage of this cardiopulmonary resuscitation (CPR) low-flow state to “prime” the heart in advance of return of restoration of spontaneous circulation. Prior investigation has demonstrated improved cardiac function after perfusing the globally ischemic heart with a cardioprotective agent under low-flow perfusion conditions (modeling CPR flow). These results raise the question as to whether CPR-generated flow can be utilized to induce pharmacological post-conditioning in the arrested heart.
Keywords
low-flow; CPR; post-conditioning; cardioprotect
Hrčak ID:
140704
URI
Publication date:
1.4.2015.
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