Professional paper

https://doi.org/10.15836/ccar.2014.314

Cutaneous Adverse Drug Reactions Induced by Amlodipine.

Saida Rezaković ; Policlinic “Eskulap” Zagreb, Croatia
Lidija Počanić ; Dubrava Clinical Hospital, Zagreb, Croatia

Abstract

Cutaneous adverse reactions associated with amlodipine have been rarely reported. Its most prevalent cutaneous side effect is fl ushing. Other recognized amlodipine associated skin eruptions, apart from urticaria and erythematous maculopapular rash which are most common allergic reactions, are rosacea and photodistributed telangiectasia which it is important not to misdiagnose as flushing, due to similarities in clinical presentations. Although these are usually mild to moderate
skin side effects, they can cause serious discomfort and affect the patient´s treatment compliance. Apart from these mild drug reactions, amlodipine use is associated with other more severe and nonpredictable
skin disorders including drug induced vasculitis and Steven Johnson syndrome. These cutaneous adverse drug reactions are characterized with high morbidity and even possible lethal outcome. Although these reactions are in general rare and uncommon in the use of amlodipine, it is important to acknowledge them as a possible hypersensitivity syndrome induced by this drug.

Keywords

cutaneous adverse drug reaction; amlodipine; photodistributed telangiectasia; Steven Johnson syndrome

Hrčak ID:

141145

URI

https://hrcak.srce.hr/141145

Publication date:

5.9.2014.

Article data in other languages: croatian

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