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METHODS FOR DETECTION OF ANTIBODIES TO HLA ANTIGENS IN PATIENTS AWAITING KIDNEY TRANSPLANTATION AND COMBINED PANCREAS-KIDNEY TRANSPLANTATION
MIRELA ANČIĆ
orcid.org/0000-0002-9854-2611
; Split University Hospital Center, Department of Transfusion Medicine, Split, Croatia
BLAŽENKO MARAVIĆ
; Split University Hospital Center, Department of Urology, Split, Croatia
MAJA RADMAN
; Split University Hospital Center, University Department of Internal Medicine, Split, Croatia
VEDRAN KOVAČIĆ
; Split University Hospital Center, University Department of Internal Medicine, Split, Croatia
Abstract
The best possibility to treat chronic renal disease is renal transplantation. Especially important fact in transplantation is the
percentage of so-called panel reactive antibody (PRA) that is focused on the human leukocyte antigen. There are several methods to determine the percentage of PRA in sensitized patients awaiting kidney transplants. The most important is the complementdependent cytotoxicity. A higher value of PRA implies greater likelihood of positive cross-match with random donor and lower probability of receiving a transplant. Comparing the sensitivity of laboratory tests for determination of PRA percentage in patient serum, it is concluded that ELISA and fl ow cytometry proved to be more sensitive and specific.
Keywords
HLA antigens; kidney transplantation; combined pancreas-kidney transplantation
Hrčak ID:
142206
URI
Publication date:
22.7.2015.
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