Cardiologia Croatica, Vol. 9 No. 3-4, 2014.
Professional paper
Contemporary treatment of hypertension by fixed-dose combination of telmisartan- hydrochlorothiazide
Goran Krstačić
orcid.org/0000-0003-0427-7229
; Institute for Cardiovascular Prevention and Rehabilitation, Zagreb, Croatia
Abstract
Fixed-dose combination of telmisartan and hydrochlorothiazide is another contemporary option of effective treatment of hypertension. It is a combination of an angiotensin II receptor blocker, telmisartan and thiazide diuretic, hydrochlorothiazide. Telmisartan reduces cardiovascular risk not only by reducing blood pressure (BP), but also by reducing other metabolic parameters that have a positive effect on cardiovascular diseases, especially selective modulation of PPAR-γ. Hydrochlorothiazide has an effect on the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equal amounts. Different combinations of telmisartan and hydrochlorothiazide (40/12.5; 80/12.5 and 80/25mg) are used in the treatment of hypertension in adults whose BP is not well controlled by using telmisartan alone or in patients who have been previously stabilized by telmisartan and hydrochlorothiazide administered separately.
Keywords
telmisartan; hydrochlorothiazide; hypertension; blood pressure; cardiovascular risk
Hrčak ID:
146876
URI
Publication date:
26.3.2014.
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