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A Coincidence of HLA-B27 Negative Spondyloarthritis and Paravertebral Non-Hodgkin’s Lymphoma – A Lesson to be Learned from the Past Experience
Marija Glasnović
; »J. J. Strossmayer« University, School of Medicine, University Hospital Centre Osijek, Clinic for Internal Medicine, Osijek, Croatia
Ljiljana Majnarić
orcid.org/0000-0003-1330-2254
; »J. J. Strossmayer« University, School of Medicine, Osijek, Croatia
Jasminka Sinčić Petričević
; »J. J. Strossmayer« University, School of Medicine, University Hospital Centre Osijek, Clinic for Internal Medicine, Osijek, Croatia
Vladimir Borzan
; »J. J. Strossmayer« University, School of Medicine, University Hospital Centre Osijek, Clinic for Internal Medicine, Osijek, Croatia
Željka Kolak
; County General Hospital Vinkovci, Vinkovci, Croatia
Aleksandar Včev
; »J. J. Strossmayer« University, School of Medicine, University Hospital Centre Osijek, Clinic for Internal Medicine, Osijek, Croatia
Elizabeta Horvatić
; »Tomislav Bardek« General Hospital, Department of Pathology and Cytology, Koprivnica, Croatia
Abstract
We reported a case of a 71-year-old woman with progressive low back pain and neurologic symptoms of lower extremities,
who in the background had the coexistence of spondyloarthritis (SpA) and non Hodgkin’s lymphoma of the
paravertebral location. This example describes a situation where SpA with minimal sacroiliac joints affection has nevertheless
led to the overt axial SpA. This situation included undifferentiated or reactive SpA, as well as unusual disease
context, presented with late-life disease onset, older age, female gender and no obvious hereditary predisposition. This
combination of comorbid factors could allow environmental and disease-specifi c factors to accumulate over time and to,
by modifying the primary, low-penetrant genetic background, lead to the development of lymphoma. By achieving better
understanding of disease pathophysiology dynamic, we will be able to improve our capabilities to navigate biologic
therapy in the future, in order to prevent the development of both, overt SpA and lymphoproliferative disease.
Keywords
Spondyloarthritis; HLA-B27 negative; non Hodgkin’s lymphoma; paravertebral location; ageing
Hrčak ID:
147812
URI
Publication date:
30.3.2015.
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