Review article
Skeletal muscle regeneration and the role of regeneration genes
Gordana Starčević-Klasan
orcid.org/0000-0001-7252-2340
; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci
Tina Martinčić
; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Marina Nikolić
; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Orijana Josipović
; Centar za rehabilitaciju Kozala, Rijeka
Stanislav Peharec
; Poliklinika za fizikalnu medicinu i rehabilitaciju „Peharec“, Pula
Dragica Bobinac
; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Abstract
Adult skeletal muscle is an extremely dynamic tissue which has a tremendous ability of regeneration after muscle injury. These processes are highly synchronized involving the activation of well-defined population of muscle stem cells called satellite cells. After injury skeletal muscle initiate a rapid and extensive repair process preventing the loss of muscle mass. The initial phase of muscle regeneration and repair is characterized by necrosis of the damaged tissue and inflammation. Almost simultaneously previous quiescent satellite cells are activated, proliferate, differentiate and fuse to form multinucleated myofibers. The regenerating (Reg) protein family has important role in the process of muscle regeneration. Reg proteins play important roles in tissue regeneration, cell growth and proliferation, cell adhesion and resistance to apoptosis. A Reg3G gene is upregulated in the early phase of muscle injury and acts as acute phase reactants and growth factor for muscle satellite cells and injured Schwann cells. Since the induction and release of Reg3G appeared to readily respond to muscle and nerve injury, Reg3G may function as mediators of the injury signal among the injured nerve and muscle, and possibly macrophages.
Keywords
denervation; nerve; regeneration; satellite cells; skeletal muscle
Hrčak ID:
148241
URI
Publication date:
1.12.2015.
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