Original scientific paper
A possible genotoxic effect of cytostatic drugs in occupationally exposed personnel
V. Brumen
; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
Đ. Horvat
; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
Abstract
The aim of the study was to determine possible mutagenic implications of occupational exposure to cytostatic agents. Twenty-one nurses handling antineoplastic drugs and a matching control group were examined. The conventional method for testing chemical mutagens, that of sister chromatid exchanges, SCE, was used. Although the results obtained in the exposed group did not significantly differ from those obtained for the controls, wide ranges of SCE values observed among the medical personnel handling cytostatic drugs confirm the suspicion of the genotoxic effect of those agents.
Keywords
interfering factors; method of slster chromatid exchange; nurses; testing of chemical mutagens
Hrčak ID:
148286
URI
Publication date:
30.3.1993.
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