Review article

Mutagenic and carcinogenic effects of vinyl chloride monomer

A. Fučić ; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
Đ. Horvat ; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
B. Dimitrović ; "Vinilplastika" Zdravstvena stanica, Zadar, Hrvatska

Abstract

The use of vinyl chloride monomer in industry dates back to the late 1930s. Today the number of occupationally exposed industrial workers is estimated to be several million. After the first described cases of cancer among workers exposed to high concentrations of this gas, extensive research was initiated into its possible mechanism of action on the living organism. This paper is a review of some current knowledge about the action of vinyl chloride monomer as a substance which after metabolic activation in the organism becomes a strong carcinogenic and mutagenic agent.

Keywords

cytogenetic chromosome analysis; genotoxic agents; plastics industry; lymphocyte; , mutageaic agents; gas intoxication

Hrčak ID:

151064

URI

https://hrcak.srce.hr/151064

Publication date:

5.6.1991.

Article data in other languages: croatian

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