Original scientific paper

https://doi.org/10.3325/cmj.2015.56.344

Urine fibroblast growth factor 23 levels in hypertensive children and adolescents

Magdalena Zając ; Department of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland
Agnieszka Rybi-Szumińska ; Department of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland
Anna Wasilewska ; Department of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland

Abstract

Aim To determine the correlation of urinary fibroblast
growth factor 23 (FGF23) excretion with blood pressure
and calcium-phosphorus metabolism.
Methods The study included 42 hypertensive (17 girls)
and 46 healthy children and adolescents (17 girls) aged
6-18 years admitted to the Department of Pediatrics and
Nephrology, Medical University of Białystok between January
2013 and December 2013. FGF23 in urine was measured
using Human Intact FGF-23 ELISA Kit.
Results Hypertensive participants had significantly higher
urine FGF23/creatinine values than the reference group
(8.65 vs 5.59 RU/mg creatinine, P = 0.007). Urine FGF23/creatinine
positively correlated with systolic blood pressure in
all participants. In hypertensive patients, urine FGF23/creatinine
positively correlated with serum calcium and negatively
with serum 25(OH)D, urinary calcium, phosphorus,
and magnesium.
Conclusion This study found that FGF23 may play an important
role in the pathogenesis of hypertension in children
and adolescents, but our results should be confirmed
by further studies.

Keywords

Hrčak ID:

151542

URI

https://hrcak.srce.hr/151542

Publication date:

15.8.2015.

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