Original scientific paper

Collagen and elastin in the liver of rats intoxicated with mercuric chloride

K. Olczyk ; Silesian Schoof of Medicine, Sosnowiec, Poland
E.J. Kucharz ; Silesian Schoof of Medicine, Sosnowiec, Poland
M. Wieczorek ; Silesian Schoof of Medicine, Sosnowiec, Poland
M. Szczebara ; Silesian Schoof of Medicine, Sosnowiec, Poland
P. Sonecki ; Silesian Schoof of Medicine, Sosnowiec, Poland

Abstract

Intoxication of rats with mercuric chloride (0.5 mg Hg/kg of body weight, daily for 10 weeks) increased the hepatic contents of soluble and insoluble collagen and elastin. The increase was associated with elevated serum aminotransferase and alkaline phosphatase activities, and decreased total protein level in serum. Inflammatory changes were found in the liver. An increase in the fibrous protein content suggests that inflammatory reaction to mercuric chloride can result in hepatic fibrosis.

Keywords

Hrčak ID:

151690

URI

https://hrcak.srce.hr/151690

Publication date:

18.7.1990.

Article data in other languages: croatian

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