Original scientific paper

https://doi.org/10.5562/cca2683

Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides

E. Kuzmann ; Institute of Chemistry, Eötvös Loránd University, Pázmány P. s. 1/A, Budapest, H-1117, Hungary
V. K. Garg ; Institute of Physics, University of Brasília, Brasília DF, Brazil
A. C. de Oliveira ; Institute of Physics, University of Brasília, Brasília DF, Brazil
L. Herojit Singh ; Institute of Physics, University of Brasília, Brasília DF, Brazil
S. S. Pati ; Institute of Physics, University of Brasília, Brasília DF, Brazil
E. M. Guimaraes ; Institute of Geosciences, University of Brasília, Brasília DF, Brazil
Tatiane O. dos Santos ; Institute of Physics, Federal University of Goiás, Goiânia, Brazil
M. Ádok-Sipiczki ; Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, H-6720 Hungary
P. Sipos ; Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, H-6720 Hungary
I. Pálinkó ; Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720 Hungary

Abstract

Layered double hydroxides (LDHs) are one of the very important nano-carriers for drug delivery, due to their many advantageous features, such as the ease and low-cost of preparation, low cytotoxicity, good biocompatibility, protection for the intercalated drugs, and the capacity to facilitate the uptake of the loaded drug in the cells. In our previous studies, Mössbauer spectroscopy was applied to monitor structural changes occurring during the incorporation of Fe(III) in MgFe- and CaFe-LDHs, and the intercalation of various organic compounds in anionic form. Recently, we have successfully elaborated a protocol for the intercalation and release of indol-2-carboxylate and L-cysteinate in CaFe-LDH. The corresponding structural changes in the LDH samples were studied by XRD, HR-TEM and 57Fe Mössbauer spectroscopy. The Mössbauer spectra reflected small but significant changes upon both the intercalation and the release of drugs. The changes in the basal distances could be followed by XRD measurements, and HR-TEM images made these changes visible.

Keywords

layered double hydroxides; Mössbauer spectroscopy; drug introduction; drug release; HR-TEM; XRD

Hrčak ID:

151712

URI

https://hrcak.srce.hr/151712

Publication date:

31.12.2015.

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