Review article

INFECTIONS IN PATIENTS WITH CIRRHOSIS AND LIVER TRANSPLANTATION

TAJANA FILIPEC KANIŽAJ ; Merkur University Hospital, Clinical Department of Internal Medicine and University of Zagreb, School of Medicine, Zagreb, Croatia
IVA KOŠUTA ; Merkur University Hospital, Clinical Department of Internal Medicine, Zagreb, Croatia
GORDANA CAVRIĆ ; Merkur University Hospital, Clinical Department of Internal Medicine, Zagreb, Croatia

Abstract

Altered immune response is a feature of both liver cirrhosis and liver transplantation. Both populations are at an increased risk of
bacterial infections, often with atypical clinical presentation. Classic features of the infl ammatory response are often absent or altered.
In advanced liver disease, bacterial infections are the leading cause of morbidity and mortality, and the risk of fatal outcome due to sepsis is twice as high as in the general population. Patient survival after liver transplantation continues to improve owing to enhanced surgical techniques and development of modern immunosuppressive protocols. A broad spectrum of often atypical bacterial infections are emerging as important posttransplantation complications. Timely diagnosis and therapeutic intervention is necessary for favorable outcome.

Keywords

infection; liver cirrhosis; liver transplantation

Hrčak ID:

151872

URI

https://hrcak.srce.hr/151872

Publication date:

27.1.2016.

Article data in other languages: croatian

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