Original scientific paper

Chronic hepatitis C viral infection in renal transplant recipients

Ivana Mikolašević ; Zavod za nefrologiju, dijalizu i transplantaciju bubrega, KBC Rijeka, Rijeka
Sandra Milić ; Zavod za gastroenterologiju, KBC Rijeka, Rijeka
Vesna Lukenda Žanko ; Odjel za gastroenterologiju, endokrinologiju i dijabetologiju, Opća bolnica dr. Josip Benčević, Slavonski Brod
Vojko Mavrinac ; Zavod za gastroenterologiju, KBC Rijeka, Rijeka
Davor Štimac ; Zavod za gastroenterologiju, KBC Rijeka, Rijeka
Ivan Jakopčić ; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Sanjin Rački ; Zavod za nefrologiju, dijalizu i transplantaciju bubrega, KBC Rijeka, Rijeka
Lidija Orlić ; Zavod za nefrologiju, dijalizu i transplantaciju bubrega, KBC Rijeka, Rijeka

Abstract

The aim was to analyze the effects of HCV infection on patients with transplant kidney and graft survival. Patients and methods: We retrospectively examined the 23-year (1990 – 2013) data of 471 renal transplant recipients (RTRs) mean age 50.2 ± 14 years who were anti-HCV negative and 21 RTRs mean age 49 ± 8 years who were anti-HCV positive at the time of transplantation. We compared graft and patients survival rates and causes of death and graft failure in HCV-positive and HCV-negative RTRs. Results: There was no significant difference due to acute rejection crisis during the first-year of follow up (p = 0.749). The mean values of serum creatinine didn’t show any significant differences after one-year (p = 0.798), two-years (p = 0.651) and five-years (p = 0.651) of follow-up between the HCV negative RTRs and HCV positive RTRs. There was no significant difference due to chronic allograft nephropathy and acute rejection crisis as the causes of the graft loss between two groups of patients. Finally, we did not find significant differences in the patients survival between the HCV positive RTRs and HCV negative groups of our renal transplant recipients (p = 0.081). Conclusion: Patients and graft survival were not affected by HCV infection. Anti-HCV positively should not preclude chronic renal failure patients from renal transplantation.

Keywords

hepatitis C; kidney transplantation; survival

Hrčak ID:

153000

URI

https://hrcak.srce.hr/153000

Publication date:

1.3.2016.

Article data in other languages: croatian

Visits: 2.165 *