Original scientific paper

Thyroid hormones and antithyroid antibodies influence infertility treatment, reproductive outcome and indications for assisted reproduction

Silvana Petretić Majnarić ; Klinički zavod za nuklearnu medicinu, KBC Rijeka, Rijeka
Neda Smiljan Severinski ; Zavod za humanu reprodukciju, Klinika za ginekologiju i porodništvo, KBC Rijeka, Rijeka
Svjetlana Grbac-Ivanković ; Klinički zavod za nuklearnu medicinu, KBC Rijeka, Rijeka
Ines Mrakovčić Šutić ; Zavod za fiziologiju i imunologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Maja Burić ; Klinički zavod za nuklearnu medicinu, KBC Rijeka, Rijeka
Tatjana Bogović Crnčić ; Klinički zavod za nuklearnu medicinu, KBC Rijeka, Rijeka
Tea Majnarić ; Medicinski fakultet Sveučilišta u Rijeci, Rijeka

Abstract

Aim: To estimate if the serum concentration of thyroid hormones, antithyroid antibodies and ultrasonographic examination of thyroid gland influence conception and reproductive outcome in infertile couples treated with methods of assisted reproduction Methods: Two hundred and twenty two (222) patients with infertility diagnosis have undergone a research during 2009 – 2015 in Department of human reproduction and Clinical department of nuclear medicine, University hospital Rijeka. The patients have undergone the anamnesis, clinical examination, ultrasound examination and we determined the levels of thyroid hormones and autoantibodies in serum. Results: The percent of patients with normal thyroid function who had spontaneous miscarriage was 29 %, whereas on patients with autoimune or subclinical thyroid gland disease was 52 %. Conclusion: Increased serum microsomal antibodies and increased incidence of miscarriage were observed also in infertile patients treated with methods of assisted reproduction with normal serum concentration of thyroid hormones. Routine determination of thyroid hormones, autoantibodies in serum and ultrasonographic examination of thyroid gland may be useful in infertility diagnosis, screening the patient with miscarriage risk, monitoring and treatment of infertility.

Keywords

assisted reproduction; autoantibodies; infertility; thyroid gland; thyroid hormones

Hrčak ID:

153002

URI

https://hrcak.srce.hr/153002

Publication date:

1.3.2016.

Article data in other languages: croatian

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