Short communication, Note

Immunotoxicity of chromium compounds: effect of sodium dichromate on the T cell activation in vitro

E.J. Kucharz ; Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
S.J. Sierakows1ki ; Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

Abstract

Human T cells, isolated from peripheral blood of healthy donors, were stimulated with phytohemagglutinin and cultured in vitro in the presence of sodium dichromate (l0-3 - 10-9 M). A high (10-3 M) concentration of sodium dichromate depressed T cell proliferation whereas low levels of dichromate (10-9 M) led to a significant decrease in interleukin 2 production. The results obtained suggest a direct toxic action of sodium dichromate on the functional activity of T cells.

Keywords

Hrčak ID:

153072

URI

https://hrcak.srce.hr/153072

Publication date:

19.1.1988.

Article data in other languages: croatian

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