Paediatria Croatica, Vol. 59 No. 4, 2015.
Original scientific paper
https://doi.org/10.13112/PC.2015.32
Seasonal variations of specifi c IgE concentrations to Betula verrucosa allergen, Bet v
Slavica Dodig
; Dječja bolnica Srebrnjak
Giorgie Petković
Branka Kristić Kirin
Abstract
Aim: to investigate seasonal diff erences in concentrations of total IgE (tIgE), specifi c IgE to birch allergen Bet v, and index of specifi c
IgE (I-sIgE) in children with hypersensitivity to birch allergen Bet v.
Methods: Children with asthma and/or rhinitis (N=19) sensitive to birch allergen Bet v. Concentrations of tIgE and sIgE to Bet v were
determined by the use of standardized UniCAP-fl uoroimmunoassay method. Also, I-sIgE was calculated. Selected biomarkers were
determined during the birch pollen season (from March to June) and out of season (during October).
Results: During the birch pollen season, concentration of sIgE to Bet v was [M(IQR) = 33.9(7.2-130.3) kIUA
/L], and out of season [M(IQR)
= 5 (2.3-32.7) kIUA
/L], p = 0.005. At the same time neither tIgE nor I-sIgE were statistically diff erent. During the pollen season, the largest
concentrations of tIgE (1378 kIU/L) and sIgE (942 kIUA
/L) was found in the child with asthma and rhinitis, also sensitive to grass,
ragweed and hazel allergens. I-sIgE was 0.68. Out of season uIgE was 146 kIU/L, sIgE to Bet v 46 kIUA
/L, and I-sIgE 0.31.
Conclusions: For precise interpretation of tIgE, sIgE to Bet v and I-sIgE blood samples should be taken during the pollen season.
Keywords
allergy and immunology; ambrosia; serum; receptors, IgE
Hrčak ID:
153118
URI
Publication date:
23.12.2015.
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