Original scientific paper
Effect of exposure to green coffee dust extract on airway reactivity
E. Žuškin
; »Andrija Stantpar« School of Public Health, Medical Faculty, University of Zagreb, Zagreb, Croatia
I. Dreshaj
; Institute of Clinical Physiology, Medical School, University of Kosovo, Prishtina
M. Jakupi
; Institute of Clinical Physiology, Medical School, University of Kosovo, Prishtina
M.A. Haxhiu
; Institute of Clinical Physiology, Medical School, University of Kosovo, Prishtina
Abstract
An experimental study on the effect of exposure to green coffee dust water-extract on airway responses to bronchoconstrictive drugs was carried out in eleven anaesthetized mongreal dogs. Inhalation of green coffee dust extract caused an decrease in respiratory frequency (FR), minute volume (MV), lung resistance (RL) and dynamic elastance (Edyn), and a slight decrease in tidal volume (VT). Changes were greater in comparison to changes following saline inhalation, although the differences were not statistically significant (P > 0.05). Inhalation of green coffee dust extract did not change significantly the sensitivity of bronchial system to aerosolized acetylcholine (ACh). Responses to ACh following pretreatment with saline or green coffee dust extract were similar in all respiratory parameters. The findings with pure green coffee dust water-extract suggest that bronchospasm in coffee workers is not due to the pharmacological activity of the water soluble agent in the dust, or due to increased bronchial reactivity.
Keywords
Hrčak ID:
153810
URI
Publication date:
24.2.1987.
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