Original scientific paper

https://doi.org/10.1515/acph-2016-0021

Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes

DONG-GI LEE ; Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea
IK SOON JANG ; Drug & Disease Target Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea
KYEONG EUN YANG ; Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea
SO-JUNG YOON ; Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea
SUJEONG BAEK ; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea
JOO YONG LEE ; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea
TATSURO SUZUKI ; National Agricultural Research Center for Hokkaido Region, Memuro, Hokkaido 0820081, Japan
KEUN-YOOK CHUNG ; Department of Agricultural Chemistry, Chungbuk National University, Cheongju 28644, Republic of Korea
SUN-HEE WOO ; Department of Crop Science, Chungbuk National University, Cheongju 28644, Republic of Korea
JONG-SOON CHOI ; Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea

Abstract

This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.

Keywords

tartary buckwheat sprout; rutin; type 2 diabetes; insulin signaling

Hrčak ID:

153874

URI

https://hrcak.srce.hr/153874

Publication date:

30.6.2016.

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