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Autoimmune Polyglandular Syndrome Type II - Case Report

Branko Bečejac
Marijo Bekić
Mira Misjak
Miljenko Solter
Milan Vrkljan

Abstract

Presentation is made of a 41-year-old man with Addison’s disease and coexistent Hashimoto’s thyroiditis and hypothyroidism. The two diseases are presumed to be of autoimmune etiology and to manifest as part of the autoimmune polyglandular syndrome type II, as also suggested by tissue typing for HLA B8 locus. Inadequate TSH suppression with standard levothyroxine substitution therapy for a one-year period or with higher substitution doses of 200 mg during TRH stimulation, with FT4 which showed no major increase but remained within lower normal limits, indicated partial hypophyseal resistance to thyroxin and/or possible development of autoantibodies to peripheral thyroid hormones.

Keywords

Polyendocrinopathies, autoimmune, diagnosis; Addison’s disease, etiology; Thyroiditis, autoimmune, diagnosis; Case report

Hrčak ID:

14882

URI

https://hrcak.srce.hr/14882

Publication date:

3.12.2001.

Article data in other languages: croatian

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