Original scientific paper
Biochemical and enzymological changes in liver and kidney of Clarias batrachus following lithium intoxication
K.A. Goel
; Department of Zoology, D. A. V. College, Muzaffarnagar, India
S.D. Sharma
; Department of Zoology, D. A. V. College, Muzaffarnagar, India
Maya
; Department of Zoology, D. A. V. College, Muzaffarnagar, India
Abstract
The present paper deals with some enzymological alterations and glycogen-glucose relationship in the liver and kidney of Clarias batrachus in response to lithium nitrate administration. The toxin was administered by intramuscular injections and the dose of 500 µg was repeated every third day. The experimental animals received a total of 7500 µg LiN03 in 15 injections. The biochemical parameters were measured comparatively in the experimental and control animals. The results show that the glycogenolysis in the liver was accelerated by lithium administration and that a decrease in hepatic glycogen was associated with increase in glucose. The activities of enzymes AlPase and AcPase increased significantly. RNase and 5'nucleotidase also increased. Decreased lactic dehydrogenase reflected a disturbance in the tricarboxylic acid cycle whereas a rise in GOT and GPT indicated an increase in transamination reactions in the tested tissues.
Keywords
Hrčak ID:
155201
URI
Publication date:
29.7.1986.
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