Conference paper

Effect of Morphologic Cell Types on the Expression of bcl-2, Ki-67 and P-53 in Uveal Melanomas

A. Krvavica
J. Talan-Hranilović
M. Belicza

Abstract

Uveal melanomas are known to be less aggressive malignant tumors compared with melanoma of other localizations but the same morphological characteristics. We hypothesized that immunohistochemical determination of expression of the known proliferation markers bcl-2 and ki-67, and p-53 as a suppressor gene marker, could better explain the biological behavior of uveal melanoma vs. melanoma of other localizations. Thirty cases of primary uveal melanoma of two levels of invasion were tested retrospectively for the presence of bcl-2, Ki-67 and p-53 proteins with the indirect peroxidase-antiperoxidase immunoenzyme method and three step ABC/AP method. The intensity of reaction was assessed by semiquantiative method.

Keywords

Bcl-2 oncoprotein; Ki-67 oncogene; p-53 supressor gene; uveal melanoma

Hrčak ID:

15208

URI

https://hrcak.srce.hr/15208

Publication date:

3.6.2002.

Article data in other languages: croatian

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