Original scientific paper
The influence of a composite treatment for internal contamination by several radionuclides on certain health parameters in rats
B. Kargačin
; Institute for Medical Research and Occupational Health, University of Zagreb, Zagreb, Croatia
T. Maljković
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
M. Blanuša
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
K. Kostial
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Abstract
The health effects of a composite treatment for the early and late therapy of internal contamination with several radionuclides were evaluated in rats. The rats were given a mixture of calcium alginate, ferrihexacyanoferrate(II) and potassium iodide orally for 10 days together with the intraperitoneal administration of Ca-DTPA in the first three days and foe oral administration of Zn-DTPA daring the remaining seven days. The health effects of this treatment were evaluated by body weight measurements, haematological and histopathological examinations and trace element analysis. The treated animals had a slightly lower number of erythrocytes, slightly Iower haemoglobin and haematocrit values and very mild histopathological changes in the kidneys in the form of hydropic degeneration of proximal convoluted tubules. The observed changes were consistent with the known effects of individual therapeutic agents (alginate, Ca-DTPA) and therefore the simultaneous administration of several agents did not alter toxicity or produce new adverse effects.
Keywords
Hrčak ID:
156778
URI
Publication date:
23.1.1986.
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