Review article

Corticosteroids-induced diabetes mellitus: modern concepts and perspectives in the treatment

Dubravka Jurišić-Eržen ; Klinika za internu medicinu, KBC Rijeka, Rijeka
Koraljka Benko ; Klinika za internu medicinu, KBC Rijeka, Rijeka
Gordana Starčević-Klasan ; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Romana Jerković ; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka

Abstract

The mechanism of corticosteroids-induced diabetes mellitus is multifactorial. Corticosteroids induce hepatic and extrahepatic insulin resistance. Corticosteroids have direct harmful effects on insulin-secreting beta cells of the pancreas, decreasing in glucose transport into the beta cells and inducing apoptosis. The risk of corticosteroids-induced diabetes increases with the corticosteroids dosage, duration of therapy, age, family history of diabetes mellitus, obesity, ethnicity and high blood glucose concentrations before corticosteroids therapy. Treatment of patients with corticosteroids-induced hyperglycaemia is diet, exercise and self-monitoring of blood glucose level. Patients with persistent fasting and daytime blood glucose concentrations over 11.1 mmol/L, the treatment with insulin is recommended.

Keywords

corticosteroids; diabetes mellitus; hyperglycemia; insulin

Hrčak ID:

158502

URI

https://hrcak.srce.hr/158502

Publication date:

1.6.2016.

Article data in other languages: croatian

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