Original scientific paper
The effects of HS-3 and HS-6 on cardiovascular changes in rats caused by soman
D. Kentera
; Institute for Medical Research, Belgrade
D. Sušić
; Institute for Medical Research, Belgrade
B. Stamenović
; Institute for Medical Research, Belgrade
Abstract
The effects of HS-3 and HS-6 on cardiovascular changes due to poisoning with the LD50 of soman were studied in anaesthetized rats. Both HS-3 and HS-6 were found to antagonize the changes in arterial blood pressure and heart rate. HS-3 was more effective than HS-6 in neutralizing the changes in cardiovascular performance induced by the central action of soman. The two oximes produced an antagonistic effect on some abnormalities in the electrocardiogram caused by soman. The primary haemodynamic effect of soman and its antidotes reflected itself on peripheral vascular resistance, the alteration in cardiac output being secondary, in the course of the homeostatic control of arterial pressure.
Keywords
Hrčak ID:
158518
URI
Publication date:
29.9.1982.
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