Original scientific paper
Effect of single and repeated administration of Δ 9-tetrahydrocannabinol on 5-hydroxytryptamine, noradrenaline, dopamine and tryptophan levels in the brain of Wistar rats
N. Filipović
; Department of Biochemistry and Medical Chemistry, Faculty of Medicine, Banja Luka, Yugoslavia
M. Trkovnik
; Department of Organic Chemistry and Biochemistry, Faculty of Technology, Banja Luka, Yugoslavia
Abstract
Single or repeated administration of Δ 9-tetrahydrocannabinol (30 mg/kg i.p.) increased 5-hydroxytryptamine levels in rats' brain, but did not affect dopamine or noradrenaline levels. Brain and blood tryptophan levels were raised only after a single¬-dose regimen. The primary effect of Δ 9-tetrahydrocannabinol may be a mobilization of blood tryptophan by displacement from its albumin-bound depots, due to a high affinity of the drug for plasma albumin.
Keywords
Hrčak ID:
159470
URI
Publication date:
28.5.1981.
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