Original scientific paper
The mechanism of chronotropic activity of caffeine and theophylline in guinea pigs
D. Atanacković
; Farmakološki institut Medicinskog fakulteta, Rijeka
A. Simonić
; Farmakološki institut Medicinskog fakulteta, Rijeka
A. Frković
; Farmakološki institut Medicinskog fakulteta, Rijeka
Abstract
The chronotropic activity of caffeine and theophylline on the isolated right atrium of the guinea pig was examinated. Theophylline caused a significant and caffeine only a slight increase in the atrial rate. Reserpine and alpha methyl DOPA diminished the chronotropic activity of the Investigated methyl xanthines. Propranolol caused a decrease in the atrial rate. Caffeine and theophylline potentiated the negative chronotropic activity of propranolol.
Keywords
Hrčak ID:
160050
URI
Publication date:
14.10.1980.
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